Ph-sensitive peptides and their nanoparticles for drug delivery

Peptides sensibles au ph et leurs nanoparticules pour l'administration de médicament

Abstract

A new nanoscale carrier made by one or more pH-sensitive peptides is provided for delivery of a biologically active substance. The peptides are composed of pH- sensitive hydrophilic and hydrophobic amino acids in the backbone. As the pH environment changes from physiological pH level to a weakly acidic environment such as near a tumor site (pH~6.5-6.9), the peptides may dissolve, releasing the biological substance. Also provided are the delivery methods and related kits.
L'invention concerne un nouveau excipient à l'échelle nanométrique constitué par un ou plusieurs peptides sensibles au pH, pour l'administration d'une substance biologiquement active. Les peptides sont composés d'acides aminés hydrophiles et hydrophobes sensibles au pH dans le squelette carboné. Alors que l'environnement de pH change d'un niveau pH physiologique à un environnement faiblement acide tel qu'à proximité d'un site tumoral (pH~6.5-6.9), les peptides peuvent se dissoudre, libérant la substance biologique. L'invention concerne également les procédés d'administration et des trousses associées.

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Cited By (1)

    Publication numberPublication dateAssigneeTitle
    WO-2016007647-A1January 14, 2016The Johns Hopkins UniversityDécouverte d'inhibiteurs de la glutaminase et administration améliorée par des nanoparticules pour la thérapie anticancéreuse